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KMID : 0358220060330030149
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Korean Journal of Fertility and Sterility
2006 Volume.33 No. 3 p.149 ~ p.157
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The Clinical Efficiency of Clomiphene Citrate vs Clomiphene Citrate/GnRH Antagonist on Infertile Women with Normal Ovulatory Cycles
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Lee Woo-Seok
Sang Jae-Hong
Kim Jae-Joon
Kim Gwang-Jun
Kim Dong-Ho
Lee Sang-Hun
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Abstract
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Objective: This study was to investigate the clinical efficiency of clomiphene citrate/GnRH antagonist protocol comparing with the clomiphene citrate only protocol in infertile women with normal ovulatory cycles.
Method: Among 116 patients, 43 were received assisted reproductive technologies using natural ovulatory cycle, 38 and 35 were received clomiphene citrate only protocol and clomiphene citrate/GnRH antagonist combined protocol,respectively, and the clinical results were compared and analyzed.
Results: In each group, basal levels of LH, FSH, E2 and FSH, E2 on hCG day injected were not different, but LH level and endometrial thickness on hCG injected day were decreased significantly and the pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group.
Conclusion: The pregnancy rate was increased significantly in clomiphene citrate/GnRH antagonist group compared with natural ovulatory cycle and clomiphene citrate only group.
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KEYWORD
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Clomiphene citrate, GnRH antagonist
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